Christian McCaffrey is active for week 1 despite calf concerns and a history of bilateral Achilles tendinopathy, signaling a heavy workload but clear injury risk. Fantasy managers should expect a high-volume yet fragile ceiling as SF navigates the early-season grind. Kyler Murray’s illness adds another layer of Week 1 uncertainty for Arizona, while Washington’s Brian Robinson Jr. and Darnell Mooney’s inactive status shape early rosters.

On the dynasty/season-long front, Garrett Wilson remains a cornerstone in New York with challenging matchups looming, and Jameson Williams’ status (plus the Rams’ surrounding weapons) keeps owners weighing upside vs risk. The show also flags Puka Nacua’s breakout potential and DJ Moore’s role in Chicago, alongside other WR and RB move pieces that fantasy managers should monitor as Week 1 unfolds.

Christian McCaffrey headlines week 1 with calf risk and a likely 4:05 ET kickoff, forcing managers to weigh a top RB1 against a reduced workload if he plays. Safe pivots behind him include James Cook, Travis Etienne, and Brian Robinson, with late-week WR decisions centering on Darnell Mooney and Jaden Reed as Mooney’s status remains in doubt and Reed’s involvement could swing flex spots in the 4 p.m. slate.

Ridley vs. Jennings becomes a high-variance call, while Andrew Thomas’ doubtful status tightens lineups across the board. The show also weighs Mooney’s game speed, Hunter’s multi-position plan, and a handful of 4 p.m./MNF options to close the week1 roster gaps.